| ClubName | Description | Moderator |
| Academic Challenge | Students compete against their peers from other schools in the annual Rutgers Academic Challenge. Past teams have ranked among the top three from South Jersey. | |
| Aries - GCHS Yearbook | The annual student-written and edited yearbook of Gloucester Catholic High School. | Mrs. Chris McKenna |
| Battle of the Bands/ GC Unplugged | Provides a showcase for student musical and poetic talent and performance. | Mr. Ed Beckett |
| Blood Drive | Sponsors events and education throughout the school community. | |
| Chess Club | The Club fosters student interest competition in Chess. | Mr. Bob Nark |
| Choir | Choir performs at many "school" functions- Mass, Prayer Services, Graduation. They also entertain in the community at other churches and nursing homes. They participate in the Camden County Teen Arts Festival. Members are eligible to become members of the Tri-M Music Honor Society. | Mrs. Schramm |
| Classical Music Club | Students learn to appreciate classical music through attendance at area concerts and listening sessions. | Dr. Jay Simmons |
| Drama "Club" | Performs a Fall Drama with a Dinner or Dessert Theatre family atmosphere. They also join other members of the school family in presenting a full-scale Broadway Musical every spring. | Mrs. Marge Stafford & Mrs. Schramm |
| Environmental Club | Encourages students to actively participate in making our world a better place to live. | Mrs. Joan Chalmers |
| Forensics | Students engage in public speaking competition.
Seven-time winners of the Camden Diocesan Bishop's Cup. | |
| Habitat for Humanity | Local chapter of the international organization dedicated to providing affordable housing in the name of the Gospel. | Mr. Ed Beckett |
| Interact | GCHS chapter of the Rotary-sponsored service organization. Coordinates the annual "toys for tots" collection and other service activities. | Mr. George Bakey & Mr. Ed Beckett |
| Model U.N. | High school version of the collegiate program where students actually serve as UN delegates at a mock session of the General Assembly.
Limited to students in Honors US History 2. | Mr. Kevin Heil |
| National Honor Society | Marian Chapter of the national service organization that recognizes academic excellence and extraordinary participation in school life. Membership is open to Juniors and Seniors, who are selected on the basis of their academic performance, service and participation in school life. The NHS sponsors and assists in a variety of student activities. | Mrs. Katharine Coghlan |
| Outdoors Club | A club devoted to encouraging students to engage in hiking and canoeing.
Four trips annually. | Mr. Ed Beckett |
| Rampage | Gloucester Catholic's student-written and edited school newspaper. Appears quarterly. | Mrs. Kathy Schilling & Mrs. Christine McKenna |
| Rams for Life | GCHS's pro-life organization fostering educational and service activities designed to increase and demonstrate our reverence for life.
Annual participant in the national gathering for life in Washington, DC. | |
| Samaritan Club | This club seeks to provide witness to our Catholic mission through service to the wider community; e.g., Cathedral Soup Kitchen. | |
| Sketch Club | Encourages the artistic expression and development of GCHS students. | Mr. David A. Sipple |
| Ski Club | Provides skiing opportunities for expert and novice skiers and sponsors an annual ski trip. | |
| Strummer's Lounge | Provides for regular meetings of student guitarists for jam sessions, song writing and general guitar picking. | Mr. Ed Beckett |
| Student Ambassadors | This student organization serves as a link between Gloucester Catholic and our community. Student ambassadors share their GCHS pride and hospitality with visitors, parents and prospective students. | Mrs. Kathy Coghlan |
| Student Council | The Student Council is the official student government organization that brings the needs and interests of the student body to the attention of the faculty and administration. Members are elected by their peers. The Student Council also oversees several community-wide activities such as dances, opportunities for service, powderpuff football, and student talent showcases. | Mrs. Anne Heim |
| World Cultures & Travel Club | Past trips have included excursions to London, Paris, and the beaches of Normandy and Stonehenge. | Mr. David A. Sipple |